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Antidepressants are among the most frequently prescribed medications in the U.S. From 2015 through 2018, more than 14% of people 12 and older said they took an antidepressant in the last month. Perhaps the most recognizable among them is Prozac (fluoxetine). It's still the best option for many people, but since it was approved by the Food and Drug Administration (FDA) in 1987, Prozac has been joined by a variety of other antidepressant medications. If you're considering taking an antidepressant, understanding how the most popular ones work can help you and a doctor decide which might work best for you.

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Science news: treat depression with these antidepressants

Antidepressants are effective to treat moderate to severe depression in adults. Five antidepressants appear more effective and better tolerated than others. A major review of 522 antidepressant trials found that all of the 21 drugs studied performed better than placebo, in short-term trials measuring response to treatment. However, effectiveness varied widely. Researchers ranked drugs by effectiveness and acceptability after eight weeks of treatment. Several drugs were more effective and were stopped by fewer people than others:

The National Institute of Mental Health estimates that in 2019, about 19 million people—or 7.8% of the U.S. population—experienced at least one major depressive episode. There are several types of depression, but major depressive disorder is one of the most common. A major depressive episode is defined as having persistent feelings of sadness, loss of interest in usual activities, changes to appetite and sleep patterns, loss of energy, difficulty concentrating, and suicidal ideation for at least two weeks, per the American Psychiatric Association.

Antidepressants are a popular treatment choice for depression. Although antidepressants may not cure depression, they can reduce symptoms. The first antidepressant you try may work fine. But if it doesn't relieve your symptoms or it causes side effects that bother you, you may need to try another. So don't give up. A number of antidepressants are available, and chances are you'll be able to find one that works well for you. And sometimes a combination of medications may be an option.

Anxiety and depression are the most common mental health problems affecting people today. Half of the people who have depression are also diagnosed with having an anxiety disorder. People with either depression or anxiety go to great lengths to relieve their distress, whether using medication or trying different natural remedies. Besides medication, there are other effective treatment options for people struggling with a mental illness– Click below to schedule your appointment.

There is no best antidepressant. It depends on you and what works for you. No research studies have shown that any class of antidepressants works better than other. Here is my list of pro’s and con’s: Selective Serotonin Reuptake Inhibitors (SSRI’s): fluoxetine (Prozac), sertraline (Zoloft), escitalopram (Lexapro), citalopram (Celexa), paroxetine (Paxil) and fluvoxamine (Luvox). SSRI’s work pretty well with minimal side effects (i.e. overall GI upset’s, weight gain, headache, diarrhea, etc. are not big issues. Yes these side effects still occur but compared to, say, statin’s to treat cholesterol problems, SSRI’s overall are well tolerated). They can cause three different sexual side effects: decrease in sex drive, trouble achieving and maintaining erection, and issues with delayed orgasm or complete absence of orgasm.

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Summary: 522 randomized controlled trials involving 21 antidepressants and 116,477 people were analyzed. It appears the most effective antidepressants (at a duration of 8 weeks) include amitriptyline, escitalopram, mirtazapine, paroxetine, and venlafaxine. While reboxetine and trazodone had notably lower efficacy ratings. Some of the most effective drugs had lower tolerability scores, however, indicating they may have a greater side effect burden. The antidepressant literature shows signs of potential bias, so the results have to be considered with that in mind. Authors: Andrea Cipriani, MD, Prof Toshi A Furukawa, MD, Georgia Salanti, PhD, Anna Chaimani, PhD, Lauren Z Atkinson, MSc, Yusuke Ogawa, MD, Prof Stefan Leucht, MD, Henricus G Ruhe, PhD, Erick H Turner, MD, Prof Julian P T Higgins, PhD, Prof Matthias Egger, PhD, Nozomi Takeshima, MD, Yu Hayasaka, MD, Hissei Imai, MD, Kiyomi Shinohara, MD, Aran Tajika, MD, Prof John P A Ioannidis, MD, Prof John R Geddes, MD

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Some antidepressants, though, are more effective and better tolerated than others, the findings showed. The researchers analyzed data from 522 trials -- published and unpublished -- that included more than 116,000 participants. Of the 21 antidepressants studied, all of them worked better than a placebo. "In the short-term, for acute depression, antidepressants seem to work modestly," said study author Dr. John Ioannidis. He's a professor of disease prevention at Stanford University in California. "They do have some benefit, on average, but they are not a panacea. Clearly, we need more effective interventions."

Medicine news: the most effective drugs for depression are sold here

Life throws you curveballs, and often, these trials take their toll on you. You can’t eat, sleep, smile, or even normally function. You just want to be alone and one by one, you see things in a negative light. Things turn darker. It could be depression. What should you do? It may be time for you to admit that you need help. People are in constant search of help, especially when it comes to coping with anxiety. The different brands of antidepressants give you components that help your body adjust to the drastic changes you’re going through. While there is a variety of products to choose from, you deserve the ones that have been proven to work. Before you get the first brand, you find, know what the best-sellers are. Let’s get into these later, but before you learn more about these medicines, you should also know more about how these medicines work.

The study’s first author, Dr Andrea Cipriani, believes this is the ‘final answer’ to the controversy over whether or not antidepressants work. The study found that antidepressants were better than placebo for moderate to severe depression. The five most effective antidepressants, according to this research, are: Amitriptyline (known as Elavil and others), 
Agomelatine (known as Melitor, Thymanax and Valdoxan), Escitalopram (known as Cipralex, Lexapro and others), Mirtazapine (known as Remeron and others), Paroxetine (known as Paxil, Pexeva, Seroxat and others)

The most effective treatment of depression is a combination of psychotherapy and antidepressants.[1] This has been proven repeatedly in medical trials. Antidepressants treat the symptoms of depression, and psychotherapy improves your thinking so that you reduce the risk of depression in the future. The treatment of depression is two-thirds/one-third. Two-thirds of your recovery comes from better coping skills, and one-third comes from antidepressants. But that one-third is important. The antidepressant helps to jump start your recovery. It improves your energy so that you can do the things you have to do to get out of depression. Without the antidepressant, you may know what you should do, but you don't have the energy to do it. No one antidepressant is more effective than any other. This has been proven many times. Newer antidepressants do not work better than older antidepressants. There are many antidepressants to choose from. But not every antidepressant works with every person. Finding the right antidepressant is a matter of trial and error. Unfortunately, no technique has been found to match patients to the right antidepressant. The only technique that is somewhat useful is to first look at antidepressants that have been effective for other members of your family.